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  • Title: Sterilization of infected bone by lyophilization and rehydration with antibiotic solutions.
    Author: Egyedi P, van Palenstein Helderman WH.
    Journal: J Maxillofac Surg; 1976 Mar; 4(1):65-6. PubMed ID: 768395.
    Abstract:
    UNLABELLED: In vitro experiments were carried out with artificially infected rib-fragments in order to find out, whether freeze-drying and subsequent sterilization with ethylene oxide and antibiotic solutions will eliminate bacteria inside the bone. RESULTS: Ethylene oxide will kill bacterial surface contaminants, but not bacteria inside the bone; rehydration with appropriate antibiotic solutions will eliminate bacteria inside the graft. Some clinical implications are mentioned.
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