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  • Title: Interaction between the antisense and target RNAs involved in the regulation of IncB plasmid replication.
    Author: Siemering KR, Praszkier J, Pittard AJ.
    Journal: J Bacteriol; 1993 May; 175(10):2895-906. PubMed ID: 7684039.
    Abstract:
    Physical analysis of RNA I, the small antisense RNA which regulates the replication of IncB miniplasmid pMU720, showed that it is a highly structured molecule containing an imperfectly paired stem closed by a 6-base hairpin loop. Mutational studies revealed that a 3-base sequence in the hairpin loop is critical to the interaction between RNA I and its complementary target in the RepA mRNA (RNA II). Furthermore, a 2-base interior loop in the upper stem was found to play an important role in facilitating effective binding between RNA I and RNA II. From these analyses, a model describing the molecular mechanism of binding between RNA I and RNA II is proposed.
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