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Title: Pathogenesis of trypan-blue-induced spina bifida. Author: Rokos J, Cekanova E, Kithierova E. Journal: J Pathol; 1976 Jan; 118(1):25-34. PubMed ID: 768431. Abstract: Congenital malformations induced in rats by the application of trypan blue were studied at variable times of their development of congenital malformations is a continuous process of structural and functional adaptation of the development embryo to focal tissue degeneration and necrosis (cell death). The primary degeneration is a transitory phenomenon, because the dead cells are phagocytosed by surviving cells. However, the damage triggers off the process of abnormal development.[Abstract] [Full Text] [Related] [New Search]