These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Non-NMDA-mediated transmission of somatosensory-evoked potentials in the rat thalamus.
    Author: Block F, Schwarz M, Sontag KH.
    Journal: Brain Res Bull; 1993; 31(5):449-54. PubMed ID: 7684314.
    Abstract:
    Somatosensory-evoked potentials (SEPs) were recorded from the somatosensory cortex of pentobarbital-anesthetized rats, in response to single electrical stimulation of the contralateral forelimb. The effects of microapplication of the selective N-methyl-D-aspartate (NMDA) antagonist, (-)-2-Amino-7-phosphonoheptanoate (AP7), and of the specific non-NMDA antagonist, 6,7-Dinitro-quinoxaline-2,3-dione (DNQX), in the ventrobasal thalamic nucleus on the amplitudes and latencies of cortical potentials were measured. The injection of DNQX resulted in a decrease in amplitude and an increase in the latency of cortical SEPs. These effects were a) dose dependent over the range 0.1 to 1.0 nmol, b) specific for non-NMDA receptors, and c) site specific. In contrast, microapplications of AP7 did not affect the SEPs. The present findings support the hypothesis that non-NMDA receptors in the ventrobasal thalamic nucleus are involved in the transmission of cortical SEPs.
    [Abstract] [Full Text] [Related] [New Search]