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  • Title: Prediction of an HLA B8-restricted influenza epitope by motif.
    Author: Suhrbier A, Schmidt C, Fernan A.
    Journal: Immunology; 1993 May; 79(1):171-3. PubMed ID: 7685314.
    Abstract:
    Alignment of previously identified HLA B8-restricted cytotoxic T-cell (CTL) epitopes revealed a common motif: x, x, K/R, x, R/K, x, W/Y, x, I/L. Of five motif-conforming peptides tested, ELRSRYWAI was found to represent a new epitope from influenza nucleoprotein (NP). High concentrations of some peptides gave cross-reactive stimulation illustrating the requirement to confirm epitope assignment with recombinant vaccinias and highlighting a potential problem of peptide-based CTL vaccines.
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