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  • Title: [A case uterine cervical squamous cell carcinoma successfully treated with preoperative carboplatin-based 5-drug-combined intraarterial infusion chemotherapy].
    Author: Suzuki Y, Adachi T, Hoshino T, Takeichi S, Yagishita M, Takayama M, Tsujino S, Miki M.
    Journal: Gan To Kagaku Ryoho; 1993 Jun; 20(8):1071-4. PubMed ID: 7685585.
    Abstract:
    Preoperative 5-drug-combined intraarterial infusion chemotherapy using carboplatin as a main component was performed in a case of uterine cervical squamous cell carcinoma of Stage IIa. The regimen employed was as follows: carboplatin (100 mg/m2) on Day 4 and 5, vincristine (0.6 mg/m2) on Day 1, peplomycin (5 mg/body) on Day 1, 2, and 3, methotrexate (5 mg/m2) on Day 2 and 3, and doxorubicin (15 mg/m2) on Day 4. These drugs were administered into the right inguinal region through a residual catheter at 3-week intervals prior to operation. After completion of 3 courses, the patient achieved a CR confirmed by pathological analysis and diagnostic imaging followed by extended radical hysterectomy. Side effects observed, especially renal disturbance and myelosuppression, were all tolerable. Intraarterial infusion chemotherapy using carboplatin was thus suggested to be useful against malignant tumors in the gynecological field.
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