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  • Title: Chromosome 12-containing markers, including two dicentrics, in three i(12p)-negative testicular germ cell tumors.
    Author: Atkin NB, Fox MF, Baker MC, Jackson Z.
    Journal: Genes Chromosomes Cancer; 1993 Apr; 6(4):218-21. PubMed ID: 7685624.
    Abstract:
    A chromosome 12-derived marker was seen in each of 3 testicular germ cell tumors that lacked the i(12p). An interesting feature of 2 of the markers was that the major part, including the centromere, of an acrocentric (a #13 and #14, respectively) was translocated onto 12p, resulting in a dicentric. In the third tumor, 13q (translocated onto 12q) was again probably involved in the rearrangement. The findings support the view that the amplification of genes on 12p represents a significant step in the development of germ cell tumors.
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