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  • Title: Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats.
    Author: Okada T, Sugie I, Aisaka K.
    Journal: Lymphokine Cytokine Res; 1993 Apr; 12(2):87-91. PubMed ID: 7686780.
    Abstract:
    Recombinant rat gamma-interferon was found to inhibit collagen accumulation induced by the intratracheal administration of bleomycin in rat lungs. gamma-Interferon also elicited a reduction in histamine content in the lungs of the bleomycin-treated rats; however, this agent did not cause any obvious changes in inflammatory cell infiltration into the lung. These results suggest that gamma-interferon inhibits the development of pulmonary fibrosis by suppressing collagen synthesis and could thus be used as a therapeutic agent for preventing this condition.
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