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  • Title: An acetazolamide-sensitive inward chloride pump in vascular smooth muscle.
    Author: Chipperfield AR, Davis JP, Harper AA.
    Journal: Biochem Biophys Res Commun; 1993 Jul 15; 194(1):407-12. PubMed ID: 7687435.
    Abstract:
    In smooth muscle cells, which have a small but significant chloride ion permeability, Cl:HCO3 exchange and (Na+K+Cl) cotransport are known to act as inwardly directed chloride pumps. However, even allowing for overestimation of [Cl]i due to intracellular interference with the Cl-recording electrodes, there remained a residual accumulation of chloride in rat arterial smooth muscle under conditions in which neither of these processes is operative. Manipulation of [Cl]i and Cl permeability using pharmacological agents whilst monitoring both Em and [Cl]i showed that an acetazolamide-sensitive mechanism, perhaps a Cl-dependent ATPase, is the third pathway for Cl accumulation.
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