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  • Title: Coordinate effects of Concanavalin A on cytoskeletal organization, cell shape, glycosaminoglycan accumulation and exoglycosidase activity in chick embryonic cultured fibroblasts.
    Author: Evangelisti R, Becchetti E, Locci P, Bodo M, Arena N, Lilli C, De Mattei M, Carinci P.
    Journal: Eur J Histochem; 1993; 37(2):161-72. PubMed ID: 7688602.
    Abstract:
    The effects of Concanavalin A on cell morphology, cytoskeleton arrangement and some metabolic activities of 11-day chick embryo fibroblasts were examined. In fibroblasts, Con A caused a dose-dependent round morphology and a change in tubulin, actin and alpha-actinin arrangement, whereas it did not modify 3H-thymidine incorporation. In addition, lectin stimulated more hyaluronic acid than sulphated glycosaminoglycan synthesis, affected glycosaminoglycan sulphation, and also reduced beta-N-acetyl-D-glucosaminidase, beta-N-acetyl-D-galactosaminidase and beta-glucuronidase activities.
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