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  • Title: Idiotype-dependent repertoire generation in the network system.
    Author: Yamamoto H.
    Journal: Crit Rev Immunol; 1993; 13(2):151-61. PubMed ID: 7688969.
    Abstract:
    The diversification of the receptors of B and T lymphocytes is determined by stepwise gene rearrangement of the V genes and the D-J segment. However, this repertoire is not yet selected within the host environment and thus is referred to as the potential repertoire. The repertoire of the peripheral mature B and T-lymphocytes is distorted and selected from the potential repertoire by various auto- and foreign antigens in the host environment and is referred to as the available repertoire. It is well documented that the peripheral T-lymphocyte repertoire is first selected in the thymus to delete or inactivate self-reactive clones. Moreover, extensive studies done during the last decade suggest that the B- and T-lymphocyte repertoires are significantly influenced by the host immunoglobulin idiotype repertoire. In this review, the role of immunoglobulin idiotypes in the selection of the B- and T-lymphocyte repertoires is discussed.
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