These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: On the mechanism of action of sodium orthovanadate in inducing histamine release from rat peritoneal mast cells.
    Author: al-Laith M, Pearce FL.
    Journal: Int Arch Allergy Immunol; 1993; 101(4):385-91. PubMed ID: 7689004.
    Abstract:
    Sodium orthovanadate produced a dose-dependent release of histamine and prostaglandin D2 from rat peritoneal mast cells. The release of histamine was selectively inhibited by the anion channel blockers SITS and DIDS, and by theophylline and dibutyryl cyclic-AMP, but was unaffected by disodium cromoglycate and lanthanum ions. Unlike IgE-directed ligands, vanadate did not produce any change in the intracellular concentration of cyclic-AMP but did promote a substantial uptake of calcium-45 from the incubation medium. This effect paralleled the release of histamine. These results are discussed in terms of the possible mode of action of vanadate.
    [Abstract] [Full Text] [Related] [New Search]