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  • Title: Penetration of four cephalosporins into tissue fluid in man.
    Author: Gillett AP, Wise.
    Journal: Lancet; 1978 May 06; 1(8071):962-4. PubMed ID: 76892.
    Abstract:
    The penetration of four cephalosporins into tissue fluid obtained with a skinabrasion technique was studied. Two oral antibiotics, cephalexin and CGP 9000, had similar pharmacology and penetrated the fluid in equivalent amounts. Cefuroxime (33% protein-bound) and cefoxitin (65-79% proteinbound) attained levels in tissue fluid which were very similar to their blood levels. The level of antibiotic in the tissues seems to be closely related to the blood level and is not adversely affected by protein binding.
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