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  • Title: Involvement of nitric oxide in basal and interleukin-1 beta-induced CRH and ACTH release in vitro.
    Author: Brunetti L, Preziosi P, Ragazzoni E, Vacca M.
    Journal: Life Sci; 1993; 53(13):PL219-22. PubMed ID: 7690108.
    Abstract:
    NG-Nitro-L-arginine, an inhibitor of nitric oxide synthase, does not influence CRH basal release but is able to modify ACTH basal secretion and to block interleukin-1 beta-induced CRH and ACTH release from rat hypothalamic and anterior pituitary cell cultures in vitro. The data suggest a different involvement of NO at hypothalamic and pituitary level.
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