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  • Title: Nitric oxide production by murine macrophages is inhibited by prolonged elevation of cyclic AMP.
    Author: Bulut V, Severn A, Liew FY.
    Journal: Biochem Biophys Res Commun; 1993 Sep 15; 195(2):1134-8. PubMed ID: 7690553.
    Abstract:
    Murine macrophages produce large amounts of nitric oxide (NO) on stimulation by interferon (IFN)-gamma and lipopolysaccharide (LPS) or a high concentration of LPS alone. Agents which increase intracellular cAMP levels inhibit cytokine production by macrophages. The effect of increased intracellular cAMP levels on NO production was investigated, using a murine macrophage cell line, J774. NO production was reduced by prolonged elevation of cAMP, but not by a transient increase.
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