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  • Title: Iron and zinc status in rats with diet-induced marginal deficiency of vitamin A and/or copper.
    Author: Van Houwelingen F, Van den Berg GJ, Lemmens AG, Sijtsma KW, Beynen AC.
    Journal: Biol Trace Elem Res; 1993 Jul; 38(1):83-95. PubMed ID: 7691135.
    Abstract:
    The hypothesis was tested that there are interactions of marginal copper and vitamin A deficiency regarding iron and zinc status. Copper restriction (1 vs 5 mg Cu/kg diet) significantly lowered copper concentrations in plasma and tissues of rats and reduced blood hemoglobin, hematocrit, and iron concentrations in tibia and femur, but raised iron concentrations in liver. Vitamin A restriction (0 vs 4000 IU vitamin A/kg diet) reduced plasma retinol concentrations and induced a fall of blood hemoglobin and hematocrit. Neither copper nor vitamin A restriction for up to 42 d affected feed intake and body wt gain. There were no interrelated effects of vitamin A and copper deficiency on iron status. Copper deficiency slightly depressed liver, spleen, and kidney zinc concentrations. Vitamin A deficiency lowered zinc concentrations in heart, but only when the diets were deficient in copper.
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