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  • Title: Modulation of voltage-dependent calcium channels by glutamate in rat cerebellar granule cells in culture.
    Author: Zegarra-Moran O, Moran O.
    Journal: Exp Brain Res; 1993; 95(1):65-9. PubMed ID: 7691644.
    Abstract:
    Voltage-dependent calcium channels of cerebellar granule cells maintained in a Ca(2+)-free depolarising solution were recorded using the cell-attached configuration of the patch-clamp technique. An increase in the maximum open probability of calcium channels and a shift in their activation curve toward more hyperpolarizing potentials were found in the presence of glutamate, a natural, excitatory amino acid. Such an increase in the activity of calcium channels was not due to ionic fluxes activated by glutamate, and was probably produced by a second messenger pathway triggered by the binding of glutamate to its receptor.
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