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  • Title: The pH-dependent anion-conducting channel of the mitochondrial inner membrane is potently inhibited by zinc ions.
    Author: Selwyn MJ, Ng LT, Choo HL.
    Journal: FEBS Lett; 1993 Sep 27; 331(1-2):129-33. PubMed ID: 7691656.
    Abstract:
    Zinc is a potent reversible inhibitor of the pH-dependent anion-conducting channel in the mitochondrial inner membrane, 50% inhibition was produced by 1.5 microM added Zn2+ at which point free Zn2+ was < or = 10(-8) M. Inhibition by Zn2+ is rapid but can be prevented or rapidly reversed by excess EDTA. Concentrations of Zn2+ higher than 4 microM caused reversal of inhibition to a variable extent depending on the anion. Under these conditions Zn2+ did not inhibit ribose entry, the phosphate transporter, or the pH-insensitive component of the NO3- uniport.
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