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  • Title: Randomized controlled study of chemoprophylaxis in transurethral prostatectomy.
    Author: Viitanen J, Talja M, Jussila E, Nurmi M, Permi J, Puolakka VM, Rintala E, Salmela H, Tiitinen J, Tuhkanen K.
    Journal: J Urol; 1993 Nov; 150(5 Pt 2):1715-7. PubMed ID: 7692109.
    Abstract:
    We studied 599 evaluable patients with benign prostatic hypertrophy at 7 urological units. Before transurethral prostatectomy the patients were randomized into 3 groups: group 1--197 patients given single-dose ceftriaxone (2 gm.), group 2--203 patients given 160/800 mg. trimethoprimsulfamethoxazole and group 3--199 controls given no antimicrobial prophylaxis. Patients with a preoperative indwelling catheter, positive urine culture, signs of active infection or preoperative antibiotic treatment were excluded. Postoperative infectious complications were demonstrated in 15 of 197 (7.6%), 25 of 203 (12.3%) and 43 of 199 (21.6%) patients in the study groups, respectively. The difference in infectious complications between groups 1 and 3 was statistically highly significant (p < 0.01) and between groups 2 and 3 it was significant (p < 0.05). Single-dose antibiotic prophylaxis proved to be useful in the prevention of serious infectious complications after transurethral prostatectomy.
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