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  • Title: [Stretch-activated channels in renal tubule].
    Author: Kawahara K.
    Journal: Nihon Rinsho; 1993 Aug; 51(8):2201-8. PubMed ID: 7692117.
    Abstract:
    The mechanosensitive (MS) ion channels have been identified in various tissue, including muscle, neuron, egg, kidney cells. The MS channels can be classified into 4 subtypes, i. e. stretch-activated (SA), curvature-sensitive, stretch-inactivated, and shear-stress activated. Channel activity of SA channels was increased in proportion to tension of the patch-membrane, but not to negative pressure of the patch-pipette. Potassium- and cation-selective (SA) channels were found in renal tubules, which were activated by cell-swelling and membrane-stretch. SA potassium channel may be responsible for a K exit pathway from cell. Ca-permeable (SA) cation channel may allow Ca into the cell. They can play an important role for the cell volume regulation.
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