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  • Title: Revisiting the role of mutagenesis in the induction of lung cancers in rats by diesel emissions.
    Author: Rosenkranz HS.
    Journal: Mutat Res; 1993 Oct; 303(2):91-5. PubMed ID: 7692283.
    Abstract:
    Recent studies have reported the induction of lung tumors in rats chronically exposed to levels of diesel-engine emissions which interfered with lung clearance. The present analysis suggests that the mutagenic substances (e.g. dinitropyrenes, polycyclic aromatic hydrocarbons) present in diesel particulates are not major contributors to rat-lung carcinogenesis. The cancers presumably result from lung "overloading" and the ensuing inflammatory response. In the absence of additional data, this putative mechanism of diesel-caused cancer cannot be extrapolated to other species at risk from exposure to diesel emissions.
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