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  • Title: L-nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats.
    Author: Rondouin G, Bockaert J, Lerner-Natoli M.
    Journal: Neuroreport; 1993 Sep 03; 4(10):1187-90. PubMed ID: 7693012.
    Abstract:
    During status epilepticus provoked by an intra-amygdala injection of kainic acid, the severity of seizures and of consequent neuronal damage was considerably increased in rats treated with L-NOARG, at a dose which completely inhibited NO synthesis. We propose that the effects of L-NOARG could be related to the loss of a retrograde inhibition exerted by NO on NMDA receptors. The complete suppression of NO formation in the brain finally facilitated the development and the generalization of seizures and their neurotoxic consequences.
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