These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cholinergic dependency of stimulatory effects of neurotensin on exocrine pancreas in rats.
    Author: Shinozaki H, Miyasaka K, Funakoshi A.
    Journal: Regul Pept; 1993 Sep 03; 47(2):205-11. PubMed ID: 7694326.
    Abstract:
    The biological activities of neurotensin, a 13-residue peptide, on the exocrine pancreas were examined in vitro using dispersed pancreatic acini and in vivo using conscious rats. Neurotensin had weak amylase stimulatory activity in vitro, but its injection at 0.6 or 2 nmol/kg/h stimulated pancreatic exocrine secretion in vivo. CR-1409, a cholecystokinin (CCK) receptor antagonist, partially inhibited neurotensin-stimulated pancreatic secretion, although neurotensin did not stimulate plasma CCK release. Atropine completely inhibited the pancreatic response to neurotensin. These results suggest that neurotensin has either a direct biological action on the exocrine pancreas or an action mediated by cholinergic nerve transmission, and that neurotensin does not have a major physiological role in inducing pancreatic secretion.
    [Abstract] [Full Text] [Related] [New Search]