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  • Title: Cyclosporin A, FK506 and rapamycin: more than just immunosuppression.
    Author: Kunz J, Hall MN.
    Journal: Trends Biochem Sci; 1993 Sep; 18(9):334-8. PubMed ID: 7694398.
    Abstract:
    The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
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