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  • Title: Maternal serum screening for neural tube defects and fetal chromosome abnormalities.
    Author: Rose NC, Mennuti MT.
    Journal: West J Med; 1993 Sep; 159(3):312-7. PubMed ID: 7694429.
    Abstract:
    Second-trimester maternal serum screening is a noninvasive means of identifying pregnant women at an increased risk for various conditions including a fetus with open spina bifida, fetal Down syndrome, trisomy 18, multiple gestation, and adverse pregnancy outcome. Combinations of several different markers are available for screening. These include alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol. In this review, we discuss the benefits and limitations of the screening tests and the suggested protocols for the care of patients.
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