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  • Title: The regulation of cholesteryl ester metabolism by 17 beta-estradiol in macrophages. Activation of neutral cholesterol esterase.
    Author: Tomita T, Sawamura F, Uetsuka R, Ikeda M, Tomita I.
    Journal: Ann N Y Acad Sci; 1995 Jan 17; 748():637-9. PubMed ID: 7695221.
    Abstract:
    The mechanism for antiatherogenic effects of 17 beta-estradiol (E2) was investigated in J774 A.1 cells incubated with beta-VLDL. E2 at physiological concentrations (0.25 and 2.5 nM) inhibited an accumulation of cellular cholesteryl esters and enhanced their hydrolysis in foam cells. These phenomena were preceded by activation of neutral cholesterol esterase through an increase in cyclic AMP-dependent protein kinase activity. 17 alpha-estradiol, progesterone, and testosterone lacked such stimulatory effects on neutral cholesteryl esterase.
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