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  • Title: In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae.
    Author: Dhople AM, Ibanez MA, Dhople AA.
    Journal: Antimicrob Agents Chemother; 1994 Dec; 38(12):2908-9. PubMed ID: 7695282.
    Abstract:
    In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.
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