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  • Title: Phosphorylation and activation of p90rsk by glycogen synthase kinase-3.
    Author: Wang QM, Vik TA, Ryder JW, Roach PJ.
    Journal: Biochem Biophys Res Commun; 1995 Mar 17; 208(2):796-801. PubMed ID: 7695638.
    Abstract:
    Recombinant p90rsk expressed from baculovirus was found to be phosphorylated and activated by glycogen synthase kinase-3 (GSK-3) in vitro. Phosphorylation of p90rsk by both GSK-3 alpha and GSK-3 beta isoforms was predominantly on threonine residues. Activated p90rsk, resulting from co-expression in insect cells with the oncogenic protein tyrosine kinase p60v-src, was able to phosphorylate GSK-3 but was a poor GSK-3 substrate. These results suggest a potentially novel regulatory connection in the signal transduction cascades in which p90rsk participates.
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