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  • Title: [Clinico-pharmacological research in studying the chronosensitivity to clofelin of hypertension patients].
    Author: Zaslavskaia RM, Akhmetov KZh, Teĭblium MM.
    Journal: Eksp Klin Farmakol; 1994; 57(5):27-9. PubMed ID: 7696898.
    Abstract:
    In a group of 25 patients with Stage II hypertensive disease, circulatory changes occurring with clofelin, 0.075 mg, were studied in various periods of a day (07.30 a. m. and 0.30, 6.30, and 8.30 p. m.) during acute clinical and pharmacological testing. The findings are indicative of the rhythm of clofelin chronosensitivity, showing its hemodynamic antihypertensive effect provision to be the most beneficial for the body at 6.30 p. m. and to be less at 0.30 p. m.
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