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  • Title: Synthesis and human immunodeficiency virus (HIV)-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety.
    Author: Kitazaki T, Asano T, Kato K, Kishimoto S, Itoh K.
    Journal: Chem Pharm Bull (Tokyo); 1994 Dec; 42(12):2636-40. PubMed ID: 7697778.
    Abstract:
    Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-1 protease inhibitors RPI-856 A, B, C and D (1). The compounds (2, 3) prepared showed high inhibitory activity, comparable to that of RPI-856 A, against HIV-1 protease in vitro.
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