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  • Title: Novel modification of ceramide: rat glioma ganglioside GM3 having 3-O-acetylated sphingenine.
    Author: Suetake K, Tsuchihashi K, Inaba K, Chiba M, Ibayashi Y, Hashi K, Gasa S.
    Journal: FEBS Lett; 1995 Mar 20; 361(2-3):201-5. PubMed ID: 7698323.
    Abstract:
    A novel O-acetylated GM3 containing 3-O-acetyl 4-sphingenine was isolated with one having a non-acetylated base from transplanted rat glioma tissue. The presence and position of the acetyl group were estimated by one- and two-dimensional proton nuclear magnetic resonance, and fast atom bombardment-mass spectrometries. In addition, the O-acetyl GM3 showed higher immunological activity toward anti-melanoma antibody in the presence of non-acetylated GM3 in complement-dependent liposome lysis than did non-acetylated or acetylated GM3 alone in the liposome, suggesting enhancement of immunological reactivity of the intact tumor cells by a small amount of O-acetyl GM3.
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