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  • Title: ["Medium weight molecules" as endogenous modulators of stress].
    Author: Volchegorskiĭ IA, Kostin IuK, Skobeleva NA, Tseĭlikman VE, Lifshits RI.
    Journal: Patol Fiziol Eksp Ter; 1994; (4):23-6. PubMed ID: 7700693.
    Abstract:
    Blood fractions of medium-weight molecules (MWM) were isolated from healthy dogs and dogs exposed to burn injury stress (24 postburn hours). MWM caused a profound modulation of restriction-induced beta-adrenergic stress manifestations (lipolytic and glycogenolytic responses) in rats. Some MM fractions suppressed thymic hypoplasia, gastric ulceration and mediated bone marrow neutrophilic elimination in immobilized rats. Latency of insulin- induced coma was also mediated by MM. The MM fractions attenuating beta-adrenergic stress manifestations were capable of potentiating bone marrow neutrophilic depletion in immobilized rats. There was a relationship between the ability of MM to reduce thymic hypoplasia and potentiate insulin sensitivity. The findings are discussed from the biological point of view as to the stress-mediating MM properties.
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