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  • Title: [Effect of malonate on various aspects of hepatic metabolism].
    Author: Davydov VV, Krisanova NV, Skorik GV.
    Journal: Patol Fiziol Eksp Ter; 1994; (4):53-5. PubMed ID: 7700705.
    Abstract:
    Malonate was tested for its effects on rat hepatic metabolism of [1,4-14C]-succinic acid and [1-14C]-glycerol. The administration of malonic acid did not limit [1,4-14C]-succinate metabolism and change the rate of radioactive labelling from [1-14C]-glycerol to the total lipid fraction, as well as the fraction of phospholipids and triacylglycerides. However, there was a reduction in the use of glycerol as a precursor of higher fatty acids and cholesterol. It is suggested that the detected effect of malonate is due to its action on oxidative decarboxylation of pyruvic acid.
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