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  • Title: Changes in the activity of antioxidant enzymes (SOD, GPX, CAT) after experimental spinal cord injury.
    Author: Kaynar MY, Hanci M, Kuday C, Belce A, Gumustas K, Kokoglu E.
    Journal: Tokushima J Exp Med; 1994 Dec; 41(3-4):133-6. PubMed ID: 7701506.
    Abstract:
    We determined time dependent changes in the levels of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) at 1, 4 and 24 hours after standardized reversible spinal cord injury in rats. In each segment (rostral, lesion, caudal) enzyme activities at 1, 4 and 24 hours were not significantly different. Without time limitation we have found that SOD and GPx activities were not significantly different (p > 0.05), but CAT activity was significantly high (p = 0.008) in the lesion segment than the rostral and caudal segment. According to our results we suggest that one of the main reason for tissue damage during such a spinal cord trauma model may be neither H2O2 nor H2O2 derived radicals.
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