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  • Title: Immunogenicity of the envelope glycoprotein of avian sarcoma virus.
    Author: Halpern MS, Friis RR.
    Journal: Proc Natl Acad Sci U S A; 1978 Apr; 75(4):1962-6. PubMed ID: 77019.
    Abstract:
    The expression of type E-specific glycoprotein in chick-helper factor-positive [chf(+)] chickens is not restricted to a certain stage of embryogenesis but persists in postembryonic life. This finding prompted an investigation of the immunogenicity of the viral envelope glycoprotein of exogenous avian sarcoma virus in chf(+) and chf(-) chickens. Sensitization of both classes of chickens resulted in the induction of detectable antibody reactivity to determinants of the glycoprotein that were type-specific as well as group-specific. Because group-specific determinants are present on type E-specific glycoprotein, these results link immunity to exogenous viral envelope glycoprotein in chf(+) chickens with autoreactivity. A model is proposed to rationalize the induction of reactivity in this system.
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