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  • Title: Effect of high-fat diet on the gene expression of pancreatic GLUT2 and glucokinase in rats.
    Author: Kim Y, Iwashita S, Tamura T, Tokuyama K, Suzuki M.
    Journal: Biochem Biophys Res Commun; 1995 Mar 28; 208(3):1092-8. PubMed ID: 7702608.
    Abstract:
    To define the biochemical and molecular basis of high-fat diet to reduce insulin secretion, the present study examined the effect of high-fat diet on the gene expression of pancreatic GLUT2 and glucokinase. Rats were isoenergetically meal-fed a high-fat or a high-carbohydrate diet for 10 weeks. Plasma glucose concentration was higher, whereas insulin concentration was lower in the rats fed a high-fat diet than in the rats fed a high-carbohydrate diet. The level of GLUT2 and glucokinase mRNA in pancreas was significantly decreased in the rats fed a high-fat diet compared with a high-carbohydrate diet. The rates of reduction in plasma insulin level, pancreatic gene expression of GLUT2 and glucokinase by high-fat feeding were about 50%. These results suggest that high-fat feeding impairs signal transduction mechanism in pancreatic beta-cells to reduce insulin secretion in rats.
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