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  • Title: Post-exercise albuminuria does not predict microalbuminuria in type 1 diabetic patients.
    Author: Bognetti E, Meschi F, Pattarini A, Zoja A, Chiumello G.
    Journal: Diabet Med; 1994 Nov; 11(9):850-5. PubMed ID: 7705021.
    Abstract:
    To investigate whether post-exercise urinary albumin excretion in Type 1 diabetic children and adolescents may prospectively predict the development of microalbuminuria, we have assessed post-exercise urinary albumin excretion before and after 6.2 +/- 1.7 years of follow-up in 66 diabetic children and adolescents. Post-exercise urinary albumin excretion rose significantly above the pre-exercise values in diabetic patients by 2.7 (-3.8 to 84.2) micrograms min-1 (p < 0.001) and in a group of 9 healthy individuals by 3.9 (-0.7 to 13.7) micrograms min-1 (p < 0.02) without significant differences between groups. Post-exercise albuminuria was greater in postpubertal than prepubertal 9.8 vs 4.3 micrograms min-1 (p < 0.03) and pubertal 9.8 vs 6.0 micrograms min-1 (p < 0.02) patients; post-exercise changes in urinary albumin excretion were also positively related to glycated haemoglobin (r = 0.293; p < 0.05). Eight out of 66 patients developed microalbuminuria at follow-up. Urinary albumin excretion at follow-up was comparable between patients with normal and abnormal post-exercise urinary albumin excretion; moreover post-exercise urinary albumin excretion was within the normal range in 5 out of 8 patients with microalbuminuria at follow-up. In conclusion post-exercise albuminuria does not seem to be a useful predictor of the onset of microalbuminuria in Type 1 diabetic children and adolescents.
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