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  • Title: Induction of mitotic- and meiotic-chromosome anomalies in mice and onion by distillery effluents.
    Author: Chaurasia OP.
    Journal: Cytobios; 1994; 79(319):229-34. PubMed ID: 7705103.
    Abstract:
    A 2% dilution of distillery effluent not only inhibited mitosis but also induced a 10-fold increase in the frequency of chromosome abnormalities in onion root-tip cells. Polyploidy and disturbances in cytokinesis were also observed. A 1% dilution of the effluent, when administered orally at 0.5 ml per day per mouse, induced a 12-fold increase in chromosome abnormalities among bone marrow cells. The latter included both gross and individual types of damage. In the primary spermatocytes, the effluent induced a 14-fold increase in abnormalities among which X-Y univalents, polyploidy and translocation were most common.
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