These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Proliferative activity of normal endometrial cells, endometrial hyperplasia cells and endometrial cancer cells using the monoclonal antibody to PCNA].
    Author: Hareyama H.
    Journal: Hokkaido Igaku Zasshi; 1994 Nov; 69(6):1427-1. PubMed ID: 7705752.
    Abstract:
    PCNA (Proliferating Cell Nuclear Antigen) index was studied by using an immunohistochemical technique in normal endometrium (n = 44), endometrial hyperplasia tissue (n = 12) and endometrial carcinoma (n = 60). In normal endometrial tissues, the PCNA index in the late proliferative phase (n = 11, 26.8 +/- 2.7% (mean +/- SE)) was the highest, and showed a significantly higher value than those of the early-mid secretory phase (n = 7, 12.5 +/- 3.4%, p < 0.01), late secretory phase (n = 11, 0.2 +/- 0.1%, p < 0.001), early proliferative phase (n = 7, 6.4 +/- 2.9%, p < 0.001) and postmenopausal endometrium (n = 8, p < 0.001). The mean PCNA index of premenopausal endometrial carcinoma (n = 17) was 17.1% and was not significantly higher than those of the proliferative phase and endometrial hyperplasia. Postmenopausal endometrial carcinoma (n = 43) presented a mean PCNA index of 19.9%, which was significantly higher than that of normal postmenopausal endometrium (p < 0.005). There was a clear relationship between the PCNA index and nuclear grade, cervical involvement, muscle invasion, lymph-vascular space involvement and lymphnode metastasis, respectively. There was a statistically significant difference in survival between a PCNA index of less than 25% and a PCNA index of 25% or above (p < 0.05). These results suggest that PCNA immunoreactivity in endometrial carcinoma cells may be clinically useful in predicting and/or determining the prognosis, and/or the necessity of adjuvant therapy.
    [Abstract] [Full Text] [Related] [New Search]