These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Central interleukin-1 beta stimulation of vasopressin release into the rat brain: activation of an antipyretic pathway.
    Author: Wilkinson MF, Horn TF, Kasting NW, Pittman QJ.
    Journal: J Physiol; 1994 Dec 15; 481 ( Pt 3)(Pt 3):641-6. PubMed ID: 7707232.
    Abstract:
    1. Arg8-vasopressin (AVP)-containing neurones of the bed nucleus of the stria terminalis (BST), which terminate in the ventral septal area (VSA) of the rat brain, provide a pathway which controls body temperature during fever. The present study was conducted to test the hypothesis that interleukin-1 beta (IL-1 beta) may trigger the antipyretic response by evoking AVP release from BST neurones projecting into the VSA. 2. The push-pull perfusion technique and radioimmunoassay were utilized to determine the AVP concentrations of retrieved VSA perfusion fluid in urethane-anaesthetized rats following BST infusion of vehicle or IL-1 beta (125 or 500 pg (2 microliters)-1). 3. Ventral septal AVP levels significantly increased from basal levels, in a dose-related manner, in response to IL-1 beta (0-500 pg). Electrical stimulation of the same areas of the BST also evoked AVP release into the VSA. 4. IL-1 beta infusions and electrical stimulation of the BST resulted in significant increases in rectal temperature. In IL-1 beta-treated animals (500 pg), the change in body temperature and VSA AVP release were negatively correlated (P < 0.001). However, external heating of the animals to approximately the same levels as electrically stimulated or IL-1 beta treated rats did not affect basal AVP release. 5. These data show that IL-1 beta is a potent stimulus for AVP release from BST neurones and supports BST involvement in neuro-immune interactions. We propose, that in addition to febrogenesis, IL-1 beta is also a key component in the process of endogenous antipyresis by activating vasopressinergic BST neurones to release AVP during fever.
    [Abstract] [Full Text] [Related] [New Search]