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  • Title: Influence of prostaglandins on glucose transport in isolated rat uterus.
    Author: Gonzalez ET, Jawerbaum AS, Novaro V, Gimeno AL, Gimeno MA.
    Journal: Prostaglandins Leukot Essent Fatty Acids; 1994 Dec; 51(6):445-50. PubMed ID: 7708810.
    Abstract:
    Glucose transport by uterine strips from ovariectomized estrogenized rats was explored. Sugar transport was significantly different from saccharose values (non-specific diffusion) only after 60 min of incubation. The addition of cytochalasin B demonstrated that we are measuring a specific mechanism for glucose transport. Insulin-enhanced sugar transport only at 0.5 or 0.25 U/ml prostaglandin E1 (PGE1), PGE2 and PGF2 alpha (10(-7) M) significantly improved glucose transport, but indomethacin (10(-6) M) failed in modifying this parameter in either control nor insulin-treated tissues. We did not observe an additive or synergistic action between PGE2 (10(-7) M) and insulin (used at maximal or submaximal concentration).
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