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  • Title: Selective blockade by yohimbine of locus coeruleus-induced inhibition of nociceptive reflex but not that of C responses of spinal dorsal horn neurons in rats.
    Author: Zhang KM, Zhao ZQ.
    Journal: Zhongguo Yao Li Xue Bao; 1994 Nov; 15(6):491-4. PubMed ID: 7709744.
    Abstract:
    The effect of alpha 2-adrenoceptor antagonist yohimbine (Yoh) on locus coeruleus (LC)-induced spinal antinociception was investigated in 18 anesthetized Wistar rats. Stimulation of LC markedly inhibited both nociceptive reflex of the posterior biceps semitendinosus (PBST) muscle and C responses of 16 wide-dynamic range (WDR) neurons of the dorsal horn. Application of Yoh (0.2%, 5-10 microliters) to the surface of spinal cord at L3-4 attenuated the LC-induced inhibition of nociceptive reflex without affecting that of C responses of 10 WDR neurons that were tested in 6 rats. The results suggested that LC may exert its inhibitory action on the nociceptive reflex via alpha 2 adrenoceptors somewhere other than the WDR neurons in the spinal dorsal horn.
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