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  • Title: [Comparative effects of calcium channel blockers and L-arginine on chronic intermittent hypoxic pulmonary hypertension in rats].
    Author: Li MR, Chen SC, Ma G.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1994 Dec; 17(6):372-4, 385. PubMed ID: 7712585.
    Abstract:
    Experiments were carried on rats to study the preventive effects of calcium channel blockers Nitrendipine, Nifedipine and L-Arginine (L- Arginine is the physiological precursor of nitric oxide in endothelium-dependent relaxation) on chronic intermittent hypoxia induced pulmonary hypertension, on the right ventricular hypertrophy and pulmonary vascular pathologic changes. The results showed (1) Nitrendipine, Nifedipine and L-arginine played significant role in preventing chronic hypoxic pulmonary hypertension and the right ventricular hypertrophy. (2) There was no significant difference between Nitrendipine, Nifedipine and L- arginine in preventing hypoxic pulmonary hypertension (P > 0.05). (3) Nitrendipine was better than Nifedipine in reducing the hypoxic pulmonary hypertension.
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