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  • Title: [Correlation of dopamine and serotoninergic components in the neurochemical organization of the emetic mechanism].
    Author: Nalótov SV, Dolzhenko AT, Komisarov IV, Talalaienko OM, Kharin MO.
    Journal: Fiziol Zh (1994); 1994; 40(1):10-4. PubMed ID: 7713217.
    Abstract:
    It was found out in experiments on the pigeons that the destruction of serotoninergic neurons of the brain after preliminary introduction (intraventricular) of 5,6-dihydroxytriptamin blocked the development mechanism of emesis evoked by cisplatin and radiation action, but increased readiness to the development of emetic reaction evoked by apomorphine. On the other hand the destruction of dopaminergic neurons of the brain by 6-hydroxydopamine did not cause emetic condition by introduction emetic-causing substances (apomorphine, cisplatin, copper sulphate) and by X-ray even with a dose, which ensures 100% emetic effect (ED100) on the control group of pigeons. The mechanism of dopamine and serotonin participation in the neurochemical organization of the emetic mechanism is discussed.
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