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  • Title: Tumour volume reduction following gamma knife radiosurgery: the relationship between X-ray and histological findings.
    Author: Ganz JC, Aanderud S, Mork SJ, Smievoll AI.
    Journal: Acta Neurochir Suppl; 1994; 62():39-42. PubMed ID: 7717133.
    Abstract:
    The case histories of two young ladies with Cushing's disease are described. Both patients were treated first with Gamma Knife radiosurgery and subsequently by microsurgery. The radiosurgery caused a marked reduction in tumour volume but only a partial relief of the endocrinopathy. Comparison of the histological findings with the radiological findings following radiosurgery indicates that confluent necrosis is not a prerequisite for a reduction in tumour volume. It seems more likely that the reduction in tumour volume is related to changes in cellular dynamics.
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