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  • Title: HLA-DR8 and acute anterior uveitis in ankylosing spondylitis.
    Author: Monowarul Islam SM, Numaga J, Fujino Y, Masuda K, Ohda H, Hirata R, Maeda H, Mitsui H.
    Journal: Arthritis Rheum; 1995 Apr; 38(4):547-50. PubMed ID: 7718009.
    Abstract:
    OBJECTIVE: To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS). METHODS: We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU. RESULTS: Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001). CONCLUSION: Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS.
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