These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Analysis of unconjugated morphine, codeine, normorphine and morphine as glucuronides in small volumes of plasma from children.
    Author: Watson DG, Su Q, Midgley JM, Doyle E, Morton NS.
    Journal: J Pharm Biomed Anal; 1995 Jan; 13(1):27-32. PubMed ID: 7718630.
    Abstract:
    A sensitive method for the analysis of unconjugated morphine, codeine, normorphine and total morphine after hydrolysis of glucuronide conjugates is described. The method was applicable to 50-microliters volumes of plasma. The analytes were converted to heptafluorobutyryl (HFB) derivatives before analysis by gas chromatography-negative ion chemical ionization mass spectrometry. Morphine and codeine were quantified against their [2H3]-isotopomers. Linearity, precision and accuracy were quite acceptable (in the 10(-10)-10(-9) g range), and the absolute limits of detection were < 1 pg.
    [Abstract] [Full Text] [Related] [New Search]