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  • Title: Short-course chemotherapy for tuberculous pleural effusion and culture-negative pulmonary tuberculosis.
    Author: Ormerod LP, McCarthy OR, Rudd RM, Horsfield N.
    Journal: Tuber Lung Dis; 1995 Feb; 76(1):25-7. PubMed ID: 7718842.
    Abstract:
    SETTING: Chest Clinics at Blackburn and Newham, UK. OBJECTIVE: To test the efficacy of a short-course regimen of 6 months rifampicin and isoniazid supplemented by 2 months initial pyrazinamide (2HRZ-4HR), in the treatment of smear and culture-negative pulmonary tuberculosis and tuberculous pleural effusion in routine clinical practice. DESIGN: The results of 152 patients with these forms of tuberculosis treated between 1981 and 1991 were analysed retrospectively. RESULTS: 127 patients, 65 with pleural effusion and 62 with culture-negative pulmonary tuberculosis, completed treatment as planned. 100 were followed up for a mean duration 20.5 months (range 4-72) for culture-negative disease and 14.6 months (range 3-46) for pleural effusion. There were no relapses, giving a relapse rate of 0% (95% confidence interval 0-3.62%). CONCLUSION: Unsupervised self-administered treatment with 2HRZ/4HR is a highly effective regimen for culture-negative pulmonary tuberculosis and tuberculous pleural effusion in service conditions.
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