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  • Title: Retinoic acid enhances connexin43 expression at the post-transcriptional level in rat liver epithelial cells.
    Author: Bex V, Mercier T, Chaumontet C, Gaillard-Sanchez I, Flechon B, Mazet F, Traub O, Martel P.
    Journal: Cell Biochem Funct; 1995 Mar; 13(1):69-77. PubMed ID: 7720192.
    Abstract:
    The mechanism by which all-trans retinoic acid (RA) stimulates gap junctional intercellular communication (GJIC) in the rat liver epithelial cell line. IAR203, was investigated. When RA, at 0.1 microM for 24-48 h, enhanced the dye transfer in IAR203 cells (x 1.4), it increased the amount of connexin43 (Cx43) in the cell-cell contact regions of the plasma membrane, as evidenced by analysis by Western blot and by immunofluorescence. It had no effect on the level of Cx43 mRNA. Freeze-fracture analysis of the size of gap junctions revealed an increase of the proportion of small gap junctions in RA-treated cells. We conclude that, in IAR203 cells, RA stimulates GJIC by acting at the post-transcriptional level of Cx43 regulation. The possibility that RA acts indirectly on the regulation of Cx43 expression, and increases the half-life of Cx43 by inducing adhesion molecules is discussed.
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