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  • Title: Specific heparin preparations interfere with the simultaneous measurement of ionized magnesium and ionized calcium.
    Author: Lyon ME, Bremner D, Laha T, Malik S, Henderson PJ, Kenny MA.
    Journal: Clin Biochem; 1995 Feb; 28(1):79-84. PubMed ID: 7720231.
    Abstract:
    OBJECTIVE: To determine whether heparin anticoagulants used for analysis of whole blood ionized calcium would influence the measurement of ionized magnesium. METHODS: The effects of zinc heparin, lithium heparin, and electrolyte-balanced heparin on the simultaneous measurement of ionized magnesium and ionized calcium in serum were determined using ion selective electrodes. RESULTS: Time-dependent biases in ionized magnesium and calcium concentrations were apparent with zinc heparin but not with lithium or electrolyte-balanced heparin. Ionized magnesium and calcium concentrations were more significantly influenced by volume-dependent changes in zinc heparin potency than with lithium or electrolyte-balanced heparin. CONCLUSION: Zinc heparin produces a significant positive bias in the simultaneous determination of ionized magnesium and ionized calcium concentrations.
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